This chapter will review the scope of anti-homeless stigma in society today, first by defining homelessness and then by examining the roots of anti-homeless sentiments through a review of the history of homelessness in the United States. The current manifestations of anti-homeless stigma as reflected in today’s local legislation, violence against the homeless population, and health care disparities will also be examined. Lastly, recommendations on how to compassionately care for and attend to the health care needs of the homeless population will be reviewed, as well as future directions that can be taken to help eliminate anti-homeless stigma in health care settings.