This article examines entries into homelessness among adults who identify as LGBTQ2S (lesbian, gay, bisexual, transgender, queer, two-spirit). Twenty LGBTQ2S adults who were currently or formerly homeless participated in one qualitative interview. Results demonstrated that the participants listed both structural (i.e., discrimination) and intrapersonal (i.e., substance use) variables related to their homelessness. In particular, substance abuse was a common antecedent of their homelessness, and some participants linked their homeless experiences to discrimination and victimization based on their sexual and/or gender identity.